Trastuzumab herceptin is humanized monoclonal antibody that interferes with the her2 receptor. The nominal content of each herceptin vial is 440 mg trastuzumab, 9. Herceptin access solutions can help identify the most appropriate patient assistance. Herceptin and its biosimilars are monoclonal antibodies that selectively bind with high affinity to the her2 protein. Slidesfinder is a sharing website for powerpoint presentations search and share. Highlights of prescribing information initial dose of 4. Herceptin trastuzumab kit herceptin trastuzumab injection, powder, lyophilized, for solution if this spl contains inactivated ndcs listed by the fda initiated compliance action, they will. If you continue browsing the site, you agree to the use of cookies on this website. Administer according to one of the following doses and schedules for a total of 52. Herceptin is a monoclonal antibody that binds to the extracellular portion of the her2 gene, preventing dimerization and the cascade that leads to the expression of growth factors. Herceptin is a monoclonal antibody that binds to the extracellular portion of the her2 gene, preventing dimerization and the. Herceptin 150mg powder for concentrate for solution for. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from.
An economic evaluation of herceptin in adjuvant setting. Find powerpoint presentations and slides using the power of, find free presentations research about herceptin mechanism ppt. Herceptin 600 mg solution for injection in vial summary of. Infusion reactions are a common side effect most of which are mild and easily managed, anaphylaxis occurs rarely. Trastuzumab, sold under the brand name herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. Resistance to trastuzumab in breast cancer clinical cancer.
Fixed dose sc formulation led to lower drug cost due to elimination of vial wastage. Herceptin is a drug used as adjuvant chemotherapy in cancer slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Herceptin trastuzumab for injection 150 mgvial is supplied in a singledose vial as a lyophilized sterile powder, under vacuum. Sep 01, 2019 herceptin was administered at 4 mgkg on the day of initiation of paclitaxel and then at a dose of 2 mgkg weekly for a total of 52 weeks. Download figure open in new tab download powerpoint. View and download powerpoint presentations on herceptin mechanism ppt. Schematic illustration showing the proposed mechanism of trastuzumab. Qualitative and quantitative composition herceptin sc vial contains 600mg5ml of trastuzumab. During and following paclitaxel, docetaxel, or docetaxelcarboplatin. Herceptin trastuzumab is a recombinant dnaderived humanized monoclonal antibody that selectively binds with high affinity in a cellbased assay kd 5 nm to the extracellular domain of the human epidermal growth factor receptor 2 protein, her2. Herceptin complete drug facts, side effects and dosages. Humanized antiher2 antibody her2 epitopes recognized by targets her2 protein hypervariable murine antibody fragment high affinity kd 0. Dailymed herceptin trastuzumab kit herceptin trastuzumab.
Herceptin breast cancer powerpoint ppt presentation. Kadcyla is a prescription medicine used as an adjuvant after surgery treatment for her2positive early breast cancer when the patient has taken neoadjuvant before surgery treatment including a taxane. It also induces apoptosis through antibodydependent cellular cytotoxicity. Permanently discontinue herceptin for a persistent 8 weeks lvef. Reconstitution with only 20 ml of the supplied bacteriostatic water for injection bwfi, usp, containing 1. Her2 testing is mandatory prior to initiation of therapy see sections 4. Jan 31, 2015 herceptin is a drug used as adjuvant chemotherapy in cancer slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The incidence and severity was highest in patients receiving trastuzumab with anthracyclinecontaining chemotherapy regimens.
Cost implications of using trastuzumab, as administered in the breast cancer. Do not confuse trastuzumab herceptin with adotrastuzumab emtansine kadcyla. Evaluate left ventricular function in all patients prior to and during treatment with ogivri. Serious infusion reactions and cardiopulmonary arrest infusion reactions. Herceptin patient assistance herceptin access solutions. Lower monitoring time and ability to administer at local. This emedtv web page describes specific indications uses for herceptin, such as treating breast cancer in adults who have undergone breast cancer surgery or for those who have not had prior. Not the best choice if you have heart, kidney, or lung problems. If so, share your ppt presentation slides online with. Ppt kadcyla her2positive breast cancer diseases market to. This emedtv resource describes in more detail how herceptin works to combat certain types of breast or stomach.
Herceptin trastuzumab, herceptin hylecta trastuzumab and. This study compared the incidences of left ventricular ejection fraction declines and heart failure with trastuzumab therapy in female breast cancer patients with normal or abnormal cardiac. Herceptin 600 mg solution for injection in vial summary. Negative 10,272 my docs and the nurses totally downplay the side effects of herceptin but the side effects are real. For more detail, see how this drug works section below. Herceptin trastuzumab side effects, images, uses, dosage. Herceptin is available as a singledose vial containing 60 mg or 150 mg of trastuzumab with the following excipients. One week after the last weekly dose of herceptin, administer 6 mgkg as an iv infusion over 30. Learn about drug imprint, side effects, uses treating, dosage, interaction, overdose, and warnings. Herceptin treatment should only be initiated by a physician experienced in the administration of cytotoxic chemotherapy. Life expectancy for these people could be calculated by adding up the mean time. Herceptin sc190507 1 australian product information herceptin sc trastuzumab solution for injection 1.
Food and drug administration fda for the treatment of. Trastuzumab in female breast cancer patients with reduced. Sep 30, 2019 herceptin trastuzumab kit herceptin trastuzumab injection, powder, lyophilized, for solution if this spl contains inactivated ndcs listed by the fda initiated compliance action, they will be specified as such. Highlights of prescribing information initial dose of 4 mg. Herceptin is marketed in the united states by genentech, in japan by chugai and internationally by roche. Kadcyla her2positive breast cancer diseases market to 2023 1 kadcyla her2positive breast cancer forecast and market analysis to 2023 order this report by calling 1 888 391 5441 or send an. Herceptin is a powder for concentrate for solution for intravenous infusion, which is supplied in a glass vial with a rubber stopper containing 150 mg of trastuzumab. To add to this complex scenario, cellular pathways from her2 activation are redundant, and activation of escape. Administration of trastuzumab products can result in subclinical and clinical cardiac failure. Herceptin, inntrastuzumab european medicines agency europa. Herceptin is used to treat cancer by affecting the cancer cells ability to grow and multiply. Some of these precautions and warnings include the potential risk of the drug. In some cases, health care professionals may use the trade name herceptin when referring to the generic drug name trastuzumab.
Herceptin may be resumed if, within 4 8 weeks, the lvef returns to normal limits and the absolute decrease from baseline is 15%. These forwardlooking statements may be identified by words such as believes, expects, anticipates, projects. Kadcyla her2positive breast cancer diseases market to 2023 is the property of its rightful owner. Some of these precautions and warnings include the potential risk of the drug causing congestive heart failure, the safety of taking the drug when pregnant or breastfeeding, and the possibility of the drug causing infusion reactions. Patient assistance options are available for eligible patients with commercial insurance, public insurance or no insurance. Serious infusion reactions occurred with the administration of erbitux in approximately 3% of patients in clinical trials, with fatal outcome reported in less than 1 in. Herceptin treatment should only be initiated by a physician experienced in the administration of cytotoxic chemotherapy see section 4. Infusion reactions are a common side effect most of which are mild and easily managed, anaphylaxis. Thus, the current package insert for trastuzumab describes three categories of reactions that may be associated with trastuzumab infusions. Download, view or print all the forms and documents you need to get started with herceptin access solutions, including enrollment forms, tips and checklists. Herceptin trastuzumab is an effective, firstline option when used together with other medicines for certain types of breast and stomach cancers, but it has many side effects and needs a lot of. Herceptesttm interpretation manual breast cancer 5 row version herceptesttm interpretation manual. It is usually given as an adjuvant therapy after the main treatment, such as surgery.
And disease response with treatment as defined by stabilization of disease. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing. Herceptin trastuzumab treatment information for her2. Ppt kadcyla her2positive breast cancer diseases market. Breast cancer free powerpoint presentation at slidesfinder a worldclass collection of free presentations in powerpoint format for students, teachers and marketing professionals alike. Herceptin trastuzumab, herceptin hylecta tm aetna precertification notification trastuzumab and hyaluronidaseoysk, 503 sunport lane, orlando, fl 32809.
Since 1998, herceptin has been used to treat more than 1. Find powerpoint presentations and slides using the power of, find free presentations research about. When using in combination with perjeta pertuzumab and docetaxel, consult product monographs for perjeta and docetaxel for further information on these drugs. Herceptin access solutions can help identify the most appropriate patient assistance option to help your patient get the herceptin trastuzumab he or she needs. This emedtv resource describes in more detail how herceptin works to combat certain types of breast or stomach cancer, and explains herceptin uses in children. Find information about herceptin, a treatment for early and metastatic breast cancer and stomachgej cancer. Herceptin was administered as above, but beginning 1 week after transplantation and continuing for 5 weeks. Eligibility for herceptin treatment is determin ed by a diagnostic test, saving time from the outset. Herceptin trastuzumab, herceptin hylecta trastuzumab. Herceptin is indicated, in combination with cisplatin and capecitabine or 5fluorouracil, for the treatment of patients with her2overexpressing metastatic gastric or gastroesophageal junction. Extending adjuvant treatment beyond one year is not recommended.
Highlights of prescribing information initial dose of. Australian product information herceptin sc trastuzumab. Herceptin trastuzumab is a recombinant dnaderived humanized monoclonal antibody that selectively binds with high affinity in a cellbased assay kd 5 nm to the extracellular. Highlights of prescribing information these highlights do not include all the information needed to use empliciti safely and effectively.
Herceptin trastuzumab is an effective, firstline option when used together with other medicines for certain types of breast and stomach cancers, but it has many side effects and needs a lot of monitoring. Subsequent doses at 6 mgkg as an intravenous infusion over 30 to 90 minutes every three weeks see dosage and administration 2. Herceptin treatment was permanently discontinued in. Herceptin enhanced the antitumor activity of doxorubicin, but results for the combination were not statistically superior to either agent alone. Subcutaneous formulation of roches herceptin approved in. Herceptesttm interpretation manual breast cancer 5 row version. Highlights of prescribing information these highlights do not. Permanently discontinue herceptin for a persistent 8 weeks lvef decline or for suspension of herceptin dosing on more than 3 occasions for cardiomyopathy. Seek emergency medical attention or call the poison help line at 18002221222. The summary of product characteristics recommends observation for 6 hours after the commencement of the first administration. Herceptin was administered at 4 mgkg on the day of initiation of paclitaxel and then at a dose of 2 mgkg weekly for a total of 52 weeks. It is used to treat a type of breast cancer that produces a specific receptor known as her2. Page 1 of 36 highlights of prescribing information these highlights do not include all the information needed to use perjeta safely and effectively. Herceptin hylecta trastuzumab and hyaluronidaseoysk fda.
Herceptin treatment was permanently discontinued in patients who developed congestive heart failure, or persistentrecurrent lvef decline see dosage and administration. Herceptin is a monoclonal antibody specifically designed. Find your interest in the form of powerpoint presentations on slidesfinder and save your valuable time. Administer according to one of the following doses and schedules for a total of 52 weeks of herceptin therapy. Incidence, risk factors, and management of infusion. On slidesfinder you get presentations from our huge library of professional ppt presentations. Herceptin trastuzumab is contraindicated in patients with known hypersensitivity to trastuzumab, chinese hamster ovary cho cell proteins, or any component of this product. Medical necessity criteria page 318 patient continues to meet the criteria identified in section iii. Financial impact of introducing sc trastuzumab herceptin. This emedtv web page describes specific indications uses for herceptin, such as treating breast cancer in adults who have undergone breast cancer surgery or for those who have not had prior chemotherapy.
Do not substitute herceptin trastuzumab for or with adotrastuzumab emtansine. What happens if i overdose herceptin, kanjinti, ogivri. Trastuzumab herceptin american journal of neuroradiology. Trastuzumab herceptin is used in neoadjuvant, adjuvant and metastatic breast cancer. It is specifically used for cancer that is her2 receptor positive. Kadcyla is a prescription medicine used as an adjuvant after surgery treatment for her2positive early breast cancer when the patient has taken neoadjuvant before surgery treatment including a taxane and trastuzumab herceptin and there is cancer remaining in the tissue removed during surgery. And disease response with treatment as defined by stabilization of disease or decrease in size of. Herceptin and its biosimilars are mediators of antibodydependent cellular cytotoxicity. Select patients for therapy based on an fdaapproved companion diagnostic for trastuzumab see dosage and. Herceptin fda prescribing information, side effects and uses. Each carton contains one singledose vial of herceptin.
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